Paroxetine HCl Oral : Uses, Side Effects, Interactions

Paroxetine hydrochloride was significantly better than placebo in improvement of the hdrs sub-factor scores, including the depre.The mean plasma concentrations in patients with creatinine clearance below 30 mL/min. Were approximately 4 times greater than seen in normal volunteers. Patients with creatinine clearance of 30 to 60 mL/min.The metabolism of paroxetine is accomplished in part by CYP2D6. Saturation of this enzyme at clinical doses appears to account for the nonlinearity of paroxetine kinetics with increasing dose and increasing duration of treatment.Obsessive compulsive disorder (OCD the recommended dose is 40 mg daily. Patients should start on 20 mg/day and the dose may be increased gradually in 10 mg increments to the recommended dose.In addition, the 10 mg and 40 mg strengths contain FD C yellow #5 lake, the 10 mg strength contains FD C yellow #6 lake, the 20 mg strength contains FD C red #40 lake and carmine, the 30 mg and 40 mg strengths contain FD C blue #2 lake, and the 40 mg strength.In general, improvement in patients starts after one week but may only become evident from the second week of with all antidepressant medicinal products, dosage should be reviewed and adjusted if necessary within 3 to 4 weeks of initiation of therapy and thereafter as judged clinically appropriate.

Paroxetine 20 mg Tablets - Summary of Product Characteristics

Paroxetine HCl Oral : Uses, Side Effects, Interactions

In steadystate dose proportionality studies involving elderly and nonelderly patients, at doses of 20 mg to 40 mg daily for the elderly and 20 mg to 50 mg daily for the nonelderly, some nonlinearity was observed in both populations, again reflecting a saturable metabolic pathway.If after some weeks on the recommended dose insufficient response is seen some patients may benefit from having their dose increased gradually up to a maximum of 60 mg/tients with OCD should be treated for a sufficient period to ensure that they are free from symptoms.Under clinical conditions, paroxetine concentrations would normally be less than 400 ng/mL. Paroxetine does not alter the in vitro protein binding of phenytoin or warfarin. Metabolism and Excretion The mean elimination half-life is approximately 21 hours (CV 32) after oral dosing of 30 mg tablets daily for 30 days of paroxetine.Families and caregivers should be advised of the need for close observation and communication with the prescriber. Paroxetine tablets are not approved for use in pediatric patients (see warnings, Clinical Worsening and Suicide Risk; precautions, Information for Patients; and precautions, Pediatric Use).A low initial starting dose is recommended to minimise the potential worsening of panic symptomatology, which is generally recognised to occur early in the treatment of this disorder. If after some weeks on the recommended dose insufficient response is seen some patients may benefit from having their dose increased gradually up to a maximum of.

Paroxetine hcl 20 mg tablet, Citalopram without prescription!

In some patients, with insufficient response to 20 mg, the dose may be increased gradually up to a maximum of 50 mg a day in 10 mg steps according to the patient's tients with depression should be treated for a sufficient period of at least 6 months to ensure that they are free from symptoms.Conjugates with glucuronic acid and sulfate predominate, and major metabolites have been isolated and identified. Data indicate that the metabolites have no more than 1/50 the potency of the parent compound at inhibiting serotonin uptake.Studies at clinically relevant doses in humans have demonstrated that paroxetine blocks the uptake of serotonin into human platelets. In vitro studies in animals also suggest that paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake.In these studies, paroxetine hydrochloride was shown to be significantly more effective than placebo in treating major depressive disorder by at least 2 of the following measures: Hamilton Depression Rating Scale (hdrs the Hamilton depressed mood item, and the Clinical Global Impression (CGI)-Severity of Illness.The mean elimination half-life is approximately 21 hours (CV 32) after oral dosing of 30 mg tablets of paroxetine daily for 30 days. Paroxetine is extensively metabolized and the metabolites are considered to be inactive.

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