Paroxetine - Wikipedia, the free encyclopedia

Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the missed dose as soon as you remember.Your family or other caregivers should also be alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically more depressed, or have thoughts.Therefore the initial dosage in the elderly should be reduced (see dosage AND administration). Drug-Drug Interactions: In vitro drug interaction studies reveal that paroxetine inhibits CYP2D6. Clinical drug interaction studies have been performed with substrates of CYP2D6 and show that paroxetine can inhibit the metabolism of drugs metabolized by CYP2D6 including desipramine, risperidone, and atomoxetine.In a study in which normal male subjects (n 15) received 30 mg tablets daily for 30 days, steady-state paroxetine concentrations were achieved by approximately 10 days for most subjects, although it may take substantially longer in an occasional patient.Tablets. Each film-coated tablet contains paroxetine hydrochloride equivalent to paroxetine as follows: 10 mgyellow (scored 20 mgpink (scored 30 mgblue, 40 mggreen. Inactive ingredients consist of dibasic calcium phosphate dihydrate, hypromellose, magnesium stearate, polyethylene glycols, polysorbate 80, sodium starch glycolate, titanium dioxide, and 1 or more of the following: D C Red No. 30

Paroxetine Uses, Dosage Side Effects - m

Paxil (Paroxetine) - Side Effects, Dosage, Interactions - Drugs

Paroxetine affects chemicals in the brain that may become unbalanced. Paroxetine is used to treat depression, obsessive-compulsive disorder, anxiety disorders, post-traumatic stress disorder (ptsd and premenstrual dysphoric disorder (pmdd). The Brisdelle brand of paroxetine is used to treat hot flashes related to menopause.In comparison to C min values after 20 mg daily, values after 40 mg daily were only about 2 to 3 times greater than doubled. Paroxetine is extensively metabolized after oral administration. The principal metabolites are polar and conjugated products of oxidation and methylation, which are readily cleared.Paroxetine metabolism is mediated in part by CYP2D6, and the metabolites are primarily excreted in the urine and to some extent in the feces. Pharmacokinetic behavior of paroxetine has not been evaluated in subjects who are deficient in CYP2D6 (poor metabolizers).Under clinical conditions, paroxetine concentrations would normally be less than 400 ng/mL. Paroxetine does not alter the in vitro protein binding of phenytoin or warfarin. Metabolism and Excretion The mean elimination half-life of paroxetine was 15 to 20 hours throughout a range of single doses of Paroxetine Hydrochloride Controlled-Release Tablets (12.5 mg, 25 mg, 37.5 mg, and 50 mg).Clinical Trials Major Depressive Disorder The efficacy of paxil as a treatment for major depressive disorder has been established in 6 placebo-controlled studies of patients with major depressive disorder (aged 18 to 73).


Paroxetine distributes throughout the body, including the CNS, with only 1 remaining in the plasma. Approximately 95 and 93 of paroxetine is bound to plasma protein at 100 ng/mL and 400 ng/mL, respectively.Caution: Extended release tablets should be swallowed whole and not chewed or crushed. Usual Adult Dose of Paroxetine for Anxiety: Immediate release tablets and suspension: Initial dose: 20 mg orally once a day with or without food, usually in the morning.Absorption and Distribution, paroxetine Hydrochloride Controlled-Release Tablets contain a degradable polymeric matrix (geomatrix) designed to control the dissolution rate of paroxetine over a period of approximately 4 to 5 hours. In addition to controlling the rate of drug release in vivo, an enteric coat delays the start of drug release until Paroxetine Hydrochloride Controlled-Release Tablets.The initial dosage should therefore be reduced in patients with severe renal or hepatic impairment, and upward titration, if necessary, should be at increased intervals (see dosage AND administration). Elderly Patients In a multiple-dose study in the elderly at daily doses of 20, 30, and 40 mg of the immediate-release formulation, C min concentrations were about.Studies at clinically relevant doses in humans have demonstrated that paroxetine blocks the uptake of serotonin into human platelets. In vitro studies in animals also suggest that paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake.

Paroxetine - Wikipedia, the free encyclopedia

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